LABORATORY OF CYCLOTRONIC RADIOPHARMACEUTICALS

The main installation of this laboratory is a high-current small-scale cyclotron MGC-20, which accelerates protons, deuterons, and helium ions within wide energy range (cyclotron-master - Lebedev Lev Stepanovich). In MGC-20 cyclotron they fabricate ¹²³I and ⁶⁷Ga, radioisotopes to be used in synthesis of radiopharmaceuticals.

MGC-20 cyclotron

This Laboratory was the place, where for the first time in Russia they had brought into practical use technologies of ¹²³I radionuclide recovery (1990) and fabricating of radiopharmaceuticals traced with iodine-123:

• sodium iodide, ¹²³I (for thyroid gland disease diagnosis);
• sodium ortho-iodine-hippurate, ¹²³I (for kidney disease diagnosis);
• meta-iodine-benzyl guanidine, ¹²³I (for endocrine system disease diagnosis);
• КПДПЖЕО, ¹²³I (for cardiologic diseases diagnosis).

Diagnostic examinations realized with the help of these radiopharmaceuticals allow to 50-100-time decrease in radiation exposure dose to a patient in comparison with usually applied medications on the bases of iodine-131.

For tumor disease diagnosis they have elaborated technologies for ⁶⁷Ga radioisotope recovery and on it's basis - fabricating of radiopharmaceutica -l "citrate of gallium-67"

General methods (isotopic exchange or complexon generating reaction) used to produce radiopharmaceuticals assure their radionuclide purity above 99.5% and radiochemical purity above 95%.

The Laboratory annually supplies radiopharmaceuticals to 20 medical institutions of Saint-Petersburg.

Publications

1. Solin L.M., Jakovlev V.A., Cheltsov A.N. et al. Production of High Radionuclide Pure ¹²³I with the (p, n) Reaction. // Proc. 7th Symp. on the Medical Application of Cyclotrons (May 22 - 25, 1995). - Turku, Finland. - 1995. - p. I 29-I 30.
2. Solin L.M., Gromova E.A., Jakovlev V.A. et al. Medical and Ecological Isotope Production at the MGC-20 Cyclotron. // Proc. 3rd Int. Conf. on Isotopes, "Isotope Production and Applications in the 21st Century" (Sept. 6-10, 1999). - Vancouver, Canada. - 1999. - p. 323-324.
3. Jakovlev V.A., Solin L.M.. Yield of the ¹²³Te (p,p')^123mTe Reaction at 15 MeV. // ibid.- p. 319-320.
4. Solin L.M., Kudelin B.K., Jakovlev V.A et al. Medical Isotopes Production at Low Energy Cyclotron. // Proc. 7th Intern. Conf. on Applications of Nuclear Techniques (June 17-23, 2001). - Crete, Greece. CD-version.
5. Solin L.M., Potapova T.S., Gromova E.A., et al. Fabricating of High-Quality Cyclotron Radio Pharmaceuticals at RPA "Radium Institute". // " Present-Day Problems of Nuclear Medicine and Radio Pharmaceutics ". - International Conference. (Obninsk. - 2000). - Reports Theses. - c. 149.
6. Solin L.M., Potapova T.S., Gromova E.A., et al. 12 Years Long Fabricating of Cyclotron Radio Pharmaceuticals at RPA "Radium Institute" // "Present-Day Problems of Nuclear Medicine and Radio Pharmaceutics". - All-Russian Scientific and Technical Conference. (Obninsk. - 2002). - Reports Theses. - p. 12.
7. Solin L.M., Zykov M.P., Shestakov B.I., et al. Progress of Works on Fabricating of Medical Isotopes at V.G. Khlopin Radium Institute. // Proceedings of V.G. Khlopin Radium Institute. - Saint-Petersburg. - 2003. - v.и. - p. 17-21.